| Mon 5-5 | Tue 5-6 | Wed 5-7 | Thu 5-8 | Fri 5-9 | Sat 5-10 | Sun 5-11 | Games | |
|---|---|---|---|---|---|---|---|---|
| ATH | SEA Severino | SEA Springs | SEA Hoglund | NYY Bido | NYY Sears | NYY Severino | 6 | |
| ARI | NYM Nelson | NYM Gallen | NYM Kelly | LAD Pfaadt | LAD Rodriguez | LAD Burnes | LAD Gallen | 7 |
| ATL | CIN Smith-Shawver | CIN Sale | CIN Holmes | CIN Schwellenbach | @PIT Elder | @PIT Smith-Shawver | @PIT Sale | 7 |
| BAL | @MIN Povich | @MIN Morton | @MIN Kremer | @LAA Sugano | @LAA Gibson | @LAA | 6 | |
| BOS | TEX Giolito | TEX Houck | TEX Bello | @KC Dobbins | @KC Crochet | @KC Giolito | 6 | |
| CWS | @KC Smith | @KC Burke | @KC Cannon | @KC Martin | MIA Wilson | MIA Smith | MIA Burke | 7 |
| CHC | SF Boyd | SF Rea | SF Brown | @NYM Taillon | @NYM Keller | @NYM Boyd | 6 | |
| CIN | @ATL Singer | @ATL Abbott | @ATL Greene | @ATL Lodolo | @HOU Martinez | @HOU Singer | @HOU Petty | 7 |
| CLE | @WSH L. Ortiz @WSH Lively | @WSH Allen | PHI Williams | PHI Bibee | PHI L. Ortiz | 5 | ||
| COL | DET Dollander | DET Freeland DET Gordon | SD Senzatela | SD Blalock | SD Márquez | 5 | ||
| DET | @COL Jobe | @COL Mize @COL Montero | TEX Skubal | TEX Flaherty | TEX Olson | 5 | ||
| HOU | @MIL Blanco | @MIL Wesneski | @MIL Valdez | CIN Brown | CIN McCullers Jr. | CIN Blanco | 6 | |
| KC | CWS Ragans | CWS Lugo | CWS Wacha | CWS Bubic | BOS Lorenzen | BOS Ragans | BOS Lugo | 7 |
| LAA | TOR Anderson | TOR Kikuchi | TOR Soriano | BAL Hendricks | BAL Kochanowicz | BAL Anderson | 6 | |
| LAD | @MIA Dreyer | @MIA Gonsolin | @MIA Knack | @ARI Yamamoto | @ARI Sasaki | @ARI May | @ARI Gonsolin | 7 |
| MIA | LAD Alcantara | LAD Quantrill | LAD Bellozo | @CWS Meyer | @CWS Cabrera | @CWS Alcantara | 6 | |
| MIL | HOU Myers | HOU Patrick | HOU Priester | @TB Quintana | @TB Myers | @TB Patrick | 6 | |
| MIN | BAL López | BAL Woods Richardson | BAL Ober | SF Paddack | SF Ryan | SF López | 6 | |
| NYY | SD Rodón | SD Schmidt | SD Fried | @ATH Warren | @ATH Rodón | @ATH | 6 | |
| NYM | @ARI Canning | @ARI Peterson | @ARI Senga | CHC Holmes | CHC Megill | CHC Canning | 6 | |
| PHI | @TB Wheeler | @TB Sánchez | @TB Luzardo | @CLE Nola | @CLE Suárez | @CLE Wheeler | 6 | |
| PIT | @STL Mlodzinski | @STL Skenes | @STL Keller | ATL Falter | ATL Heaney | ATL Mlodzinski | 6 | |
| SD | @NYY Pivetta | @NYY King | @NYY Cease | @COL Vásquez | @COL Kolek | @COL Pivetta | 6 | |
| SF | @CHC Roupp | @CHC Verlander | @CHC Ray | @MIN Hicks | @MIN Webb | @MIN Roupp | 6 | |
| SEA | @ATH Miller | @ATH Hancock | @ATH Woo | TOR Castillo | TOR Evans | TOR Miller | 6 | |
| STL | PIT Mikolas | PIT Liberatore | PIT Gray | @WSH Fedde | @WSH Pallante | @WSH Mikolas | 6 | |
| TB | PHI Rasmussen | PHI Baz | PHI Pepiot | MIL Littell | MIL Bradley | MIL Rasmussen | 6 | |
| TEX | @BOS Eovaldi | @BOS Mahle | @BOS Leiter | @DET Corbin | @DET deGrom | @DET Eovaldi | 6 | |
| TOR | @LAA Ureña | @LAA Berríos | @LAA Bassitt | @SEA Gausman | @SEA Francis | @SEA Ureña | 6 | |
| WSH | CLE Irvin CLE Lord | CLE Soroka | STL Parker | STL Williams | STL Gore | 5 |